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Best Drain Cleaner Comprehensive Guide For 2021

Last Updated: 15 June 2021

If only you could get rid of every clogging issue in your pipes, then you would not have to worry. Having a clogged drain is one of the worst things you could experience because nothing goes down, and this can be toxic for you.

Everybody has had a negative experience with a cleaner. And you may think that the best drain cleaner does not exist, so you just deal with what you have. But the thing is that all cleaners are made for different types, so you need to have one for every kind of purpose. For instance, you need a drain cleaner that can be used for the kitchen sink and so on and so forth. As you can see, there are a lot of features you have to know and understand. That's rather confusing!

However, there is no need to worry anymore because we've created this comprehensive drain cleaner guideline for you. All you need is to read our post and choose the one that suits you best!

Home Maker Guide created for informational purposes only. Thus, we neither endorse you in any way to buy specific products in our reviews, nor making you act like it’s written in our guides. We are reserving the rights for you to make your personal decision.



Editor-in-Chief of the Home Maker Guide
What is the best chemical to unclog drains?

Top 10 Best Drain Cleaners

Best Overall: Most Effective - Thrift Marketing GIDDS-TY-0400879 2 lb.

Thrift Marketing GIDDS-TY-0400879 2 lb. Review

The Thrift Marketing GIDDS-TY-0400879 Drain Cleaner is a highly durable product that can withstand harsh cleaning requirements. Aside from that, this drain cleaning product works in less than 60 seconds so that it will not take a lot of your time and still do other things. In case of an issue with your sewer line, septic system, or grease strap, you can use this best sewer line cleaner as well. There is no need to worry about using this cleaner on your kitchen or lavatory surface because it is very safe for those areas.

Why We Like It

  • Works as advertised because it opens the drain right away, and there are no undesirable effects
  • You do not need to use a lot to make it work again because ¼ cup is enough to unclog a bathroom sink
  • Cleans grease, hair, and soap residue really quickly which is what they promised
  • Works really well with hot water, and you do not need anything else to make it work

For Multiple Drain Types: Easiest To Apply - Liquid-Plumr Pro-Strength Clog Remover Review

Liquid-Plumr Pro-Strength Clog Remover

The Liquid-Plumr Pro-Strength Clog Remover is a drain pipe cleaner that contains 70% more actives to clear up slow-running drains. Use this leach and drain field opener on all pipes, even PVC, old drain pipes, and plastic or metal. There is no need for a snake or other tools if you use this most powerful drain cleaner because it works really well. Even if your house is old, you can rely on this drain clog remover; it won't damage your copper pipes. It is mild on the pipes but strong against anything that causes the pipes to drain slowly.

Why We Like It

  • Safe to use even if you have PVC pipes just do not let it sit there for a long time
  • Can unclog your drain even if there has been a buildup of long hair and other stuff for months
  • Most of the time, it works in 15 minutes which is what they have advertised
  • Compared to other drain cleaners, this has easy to understand instructions

Safe & Odorless: XIONLAB Safer Review


The XIONLAB Safe is one of the natural cleaners, and it is a thick liquid that will never splash on your hand or arm. Among drain cleaning products, this one is a safe substance to use because it is non-corrosive, unlike other acid drain openers. It will not leave any burnt smell after using it. No biological enzymes will be harmed, and it is powerful enough to get rid of anything in your pipes that causes the water not to go down.

Why We Like It

  • You only need to use it once if you need to get rid of the slime and rotten food in your pipe, it's really effective
  • It is a long-lasting product. You don't need much to apply
  • Not full of harsh chemicals that can hurt your skin
  • Non-toxic, no smell

Great For Bathroom Sinks: Zep Defense Drain Opener Review

Zep Defense

The Zep Defense is an enzyme drain cleaner that has a formula that breaks down years of buildup that caused your pipes to clog. The certified biodegradable formula of this is ideal for sinks, showers, and toilets while it breaks down into carbon dioxide (CO2), water, and minerals. This is available in 63-ounce bottles, and it is recommended that you use this every month to maintain clean pipes at home. You will no longer have a slow drain after letting this sit for a while before flushing it down.


  • An enzyme product that can break stuff down so your pipes will be unclogged
  • Since it breaks down into carbon dioxide, minerals, and water, your pipes will not get damaged
  • You can hear the water flowing very freely after using this product because everything is dissolved
  • Cleans everything in your pipes, not leaving anything behind; even a foul smell


  • Requires repeated use before it works, but when it does, your pipes are like new

Cheap: ComStar 0249244305003 Pure Lye Bead Review

ComStar 0249244305003 Pure Lye Bead

The ComStar contains 99% pure lye bead, with industrial-strength, biodegradable, and food grade. The formula of this best drain opener does not contain dyes, water, or useless fillers, so what you are getting is the pure substance of what it is. You can use this on fine fixtures, plastic pipes, and chrome. Besides, this clog remover does not have any acid smell or any chemical odor that other products like this have. The unique bead shape makes it sink to the bottom and attack whatever is causing the blockage.


  • Once you pour it after the hot water, there is no bubbling or anything, so it does not emit any harmful fumes
  • A drain is free-flowing again after one treatment, which makes them seem new
  • Since this product is lye, it will not ruin your pipes while it takes care of tough clogs
  • There is no need to leave this overnight for it to work because it only takes minutes


  • Put enough water because it can buildup in the pipe if it does not flow down, but mostly works as advertised

Versatile: Drano Max Gel Clog Remover Review

Drano Max Gel Clog Remover

The Drano Max Gel can be used as a commercial drain cleaner for sink that fights through standing water to unclog it. You can dissolve grease clogged drain cleaner in your bathroom, kitchen, basement, laundry room, garage, workshop, tub, shower, etc. Even if you have an old house, this is safe enough to use on all kinds of pipes even if they are old. The formulation is thick to get rid of tough clogs quickly without splashing when poured inside. You will also be happy to know that this works in 7 minutes as advertised, which is quicker than most.


  • You normally do not have to pour more than once even when there is a severe buildup in the pipes
  • There is no nasty smell at all, and it does not harm the septic system even if you have to pour several times
  • There are two bottles included in the deal which is a great value and works great
  • Can also be used as a preventive formula to keep it from getting clogged again, so there is no need to worry about it for months


  • Hard to determine 1/5 of the bottle, so you need to estimate it to avoid pouring too much

Safe To Use In All Types Of Plumbing: Professor Amos SuperFast Review

Professor Amos SuperFast

The Professor Amos SuperFast Drain Cleaner is easy, fast, and powerful to use against a massive buildup in the pipes. This makes hair, food buildup, and grease disappear from the pipes so it can break through tough clogs. You can use this best drain cleaner in sinks, floor drains, tubs, and other plumbing needs. You will not have to deal with unpleasant and toxic standing water in your pipes again because this is also a drain opener that will make everything flow freely again. You will notice that this is safe to use, and one bottle is suitable for 4 to 6 applications.


  • If you have a septic system and poly drain, this product is safe to use for all of those
  • There is no harsh odor compared to other drain cleaning products because there is no chemical smell
  • After pouring one cup inside and letting it sit for 30 minutes, it works like new again
  • Even if you have long hair, this stuff can handle dissolving them in your drain, but safe on pipes


  • Quite expensive compared to others, but still an excellent chemical drain cleaner that works

High Density: Green Gobbler Ultimate Main Review

Green Gobbler Ultimate Main

The Green Gobbler enzyme drain cleaner can dissolve organic material like oils, hairs, grease, soap scum, and even baby wipes. This liquid drain cleaner is non-damaging to pipes also there is industrial strength, while it handles the toughest clogs. Besides, this is a liquid drain cleaner that is environmentally friendly and safe to use. You will notice that it is odorless and non-flammable. You can use this septic safe drain cleaner if you have issues there as well. The formula sinks to the bottom and clings to pipes so that obstructions can be removed.


  • Gets rid of sewer gas and odor that is coming from clogged drains and pipes
  • Works effectively on a slow running toilet, especially if you leave it there overnight and try flushing the next morning
  • There is no lingering smell after it breaks down the sludge, so even people with a sensitive nose can use this
  • A non-corrosive cleaner that works great for any kind of pipes


  • Not a strong enough product for some, but it still does an excellent job for most customers who bought it

Completely Safe For People: Bio-clean Septic Bacteria Review

Bio-clean Septic Bacteria

The Bio-clean is a special mixture of natural bacteria and enzymes which is effective in digesting the dead organic waste in your plumbing system. You can use this home drain cleaner for up to 100 treatments, which saves you a lot of money. This is a drain gel that you can use for kitchen sinks, bathtubs, showers, garbage, disposals, septic tanks and fields, motor homes, cat litter pans, etc. Once the formula is in your pipes, it will eat through the gunk to restore the full capacity of your drain.


  • This is a treatment which you need to do for about three days only, and after that, there is no need to re-do it for months
  • If you follow the instructions carefully, there is no need to do it again for a year or two
  • An inexpensive way to keep your pipes free of clogs for a long time
  • The benefits are long-term and preventive instead of only dealing with the problem


  • There is a smell while you are doing the treatment, but it completely goes away after you are done

Innovative Formula: Dissolve Drain Cleaner Review

Dissolve Drain Cleaner

Its formula is ultra-thick to remove hair clogging, and it clings to pipes, so they are kept free and flowing. This best drain opener is enough to liquefy hair, paper, soap scum, and other stuff to clear up the pipes. Among the drain cleaner reviews here, this is the only one that is safer than sodium hydroxide for cleaning drains. Also, this drain cleaner is simple to use, and it only takes minutes for this to work and gets rid of anything that is causing the water not to flow properly.


  • It is explicitly great drain opener for hairclogs even if you have long hair because of the powerful formula of this product
  • Amazing for a slow-moving bathroom sink, and it works fast without any horrible chemical smell
  • You do not need goggles to use this because it does not irritate your eyes and no bad smell
  • This best rated drain cleaner is not an environmental pollutant, which means it will not hurt you as well


  • It may not be for a super heavily clogged drain if you only pour it once, so make sure to do it again if the flow is prolonged

How to Choose the Best Drain Cleaner


The most crucial consideration when you are choosing a drain cleaner is the reason why you need it. You might want to buy one that cleans your clogged drains effectively but will also prevent choked drains in the future. You need a powerful one to clear a clog, but a mild one will do for daily maintenance.

Cause of the clog

Cause of the clog

There are a lot of things that cause drains to clog, but if it is because of hair, you need a drain cleaner and a strainer to stop hair. You will need a drain brush so you can drag the hair out of the drain.

If the kitchen sink is clogged, it might be because of food sticking in the drain pipe. You need a drain cleaner that breaks down food to help you clean it easily.


You should not be pouring very toxic chemicals inside, especially if you have pets or children in the house. If you are using it for your toilet, kitchen, and bathroom drains, stay away from chemicals.

As much as possible, using natural drain cleaners are advisable, but in case none of that works, try the chemical ones but take proper precaution. The caustic type utilizes substances like caustic potash and lye-based chemicals that provide electrons to substances that are causing the clog. The reaction of hydroxide-based ions helps dissolve substances and then clear the clog.

The acid cleaners are not usually sold in retail stores, and only professional plumbers can buy them because they have a high concentration of hydrochloric acid or sulfuric acid. They work to increase hydronium ions to draw in electrons from the clog. This reaction leads to heat that can melt substances like grease, fat, and oil.

What is your budget

There are expensive and cheap drain cleaners because it depends on the brand and kind of cleaner you are buying. Keep in mind that expensive does not always mean it is the best, and cheap ones can also be very effective. You need to clean the drain effectively to avoid a clogged drain. Usually, people go for the mid-range drain cleaner because they are suitable for maintenance. The more expensive ones are for bigger unclogging jobs like if you have a severe buildup that has accumulated for months or years.


Compared to others, enzymatic drain cleaners are safe and more friendly to the environment because they do not cause water and soil leakage. They use enzymes and bacteria that eat biodegradable waste. The setback of using this is that they need more time to work compared to chemical-based cleaners. It may also take a couple of hours to unclog. They are less toxic than the chemical ones, but caution is still required when using them.

Commercial Cleaners

Commercial cleaners

They are harmful to your household, and if some cleaner splashed on your skin, eyes, or you inhaled too much, serious injury could happen. Also, if cleaners are left out or not stored in a safe location, pets and young children will become curious. This is a risk of accidental exposure or fatal ingestion. Make sure there is a safe place to store this type of cleaner before buying.

Types of Drain Cleaners

Enzyme Drain Cleaner

Enzyme Drain Cleaner

An enzyme drain cleaner does not contain any chemicals that are effective for cleaning drain pipes. It contains bacteria cultures and concentrated enzymes that respond to organic substances. They are better for the environment because the bacteria naturally feed on organic waste like hair and food waste.

Caustic Drain Cleaner

A caustic drain cleaner contains sodium hydroxide or sulfuric acid that are corrosive to a lot of metals and organic materials. They can quickly clear a clog, but it can burn clothes and skin. When caustic soda and water are mixed together, it will start to “fizz” and pour this inside.

Acidic Drain Cleaner

The strong common base of an acidic drain cleaner is lye with a formula of sodium hydroxide, but this is safe for septic systems.


How Do You Get Rid of the Sink Drain Build Up?

You first have to boil water, then pour the liquid. When the water is already boiled, you can pour the grease clogged drain liquid. Once you have poured the right amount, allow it to sit there for a couple of hours. You will see it cleared when you come back.

What is the Best Drain Cleaner?

The best drain cleaner should be non-toxic yet extremely effective, safe to use on all kinds of pipes, and environmentally friendly. Besides, it should be non-corrosive and free of chemicals. The cleaner should also not take a long time before it works because it will only take up a lot of time.

What is the Best Chemical to Unclog Drains?

The best chemical to unclog drains is caustic soda, but you can first try baking soda and vinegar because they are natural substances. Some people also use a drain snake if they do not want to pour anything in the pipes.

What Will Dissolve Hair in the Drain?

You can use vinegar to dissolve hair in the drain or purchase a cleaner that has a hair dissolver chemical. Some of them will say in the bottle that it is specifically for long hair clogs, and that is what you will need. Other drain cleaners are effective too, but these work faster in dissolving hair.

What is the Best Enzyme Drain Cleaner?

The best enzyme drain cleaner is the Bio-clean Drain Septic Bacteria, 2 which is a treatment formula that can be used to prevent clogging again. You can use this for up to 100 treatments, so even if it takes patience before you see results, you will not regret using it.

Which Drain Cleaner Works Best?

Our Recommendation

What is the best enzyme drain cleaner?

Our recommendation for the best drain cleaner 2021 is the Thrift Marketing GIDDS-TY-0400879 2 lb due to its effectiveness. Aside from that, there are no harsh chemicals, so it will not hurt your eyes, nose, or anyone else around you. Furthermore, a lot of people like this best drain cleaner 2021 because they do not have to use it often. You can prevent tough clogs from happening again. This cleaner can also handle hair clogs when there is a buildup for months already. It boasts great features! Give it a try!

You can refer to any product that homemakerguide reviewed because all of them are effective. You will no longer be confused and overwhelmed about having to look at thousands of products because the 10 best drain cleaners are here.

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